4-(2-Chlorooxazol-5-yl)benzonitrile → HCID 178509592、化合物
反応式
Cl[C:2]1[O:3][C:4]([C:7]2[CH:14]=[CH:13][C:10]([C:11]#[N:12])=[CH:9][CH:8]=2)=[CH:5][N:6]=1.[NH:15]1[C:19]([C:20]2[CH:21]=[C:22]([CH:24]=[CH:25][CH:26]=2)[NH2:23])=[N:18][N:17]=[N:16]1>CC(O)C>[NH:18]1[C:19]([C:20]2[CH:21]=[C:22]([NH:23][C:2]3[O:3][C:4]([C:7]4[CH:14]=[CH:13][C:10]([C:11]#[N:12])=[CH:9][CH:8]=4)=[CH:5][N:6]=3)[CH:24]=[CH:25][CH:26]=2)=[N:15][N:16]=[N:17]1参加物
4
反応条件
- 温度
- 80 °C
実験手順
A mixture of 4-(2-chlorooxazol-5-yl)benzonitrile 2 (0.216 g, 1.05 mmol) and commercially available 3-(1H-tetrazol-5-yl)aniline 35 (0.17 g, 1.05 mmol) in 2-propanol (20 mL) was heated to 80° C. for 18 h with stirring. Upon cooling, a white solid precipitated out which was filtered off, washed with 2-propanol, and dried. This was further purified by dissolving into DMSO and re-precipitated with addition of water. Resulting solid was filtered, washed with water, methanol and dried under high vacuum to yield 4-(2-((3-(1H-tetrazol-5-yl)phenyl)amino)oxazol-5-yl)benzonitrile 36 as a white solid (0.348 g, 100%). MS (ES) m/z 330 (M+H+).