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HRID 537872作成日：2026年10月24日
N-(3-Amino-phenyl)-C,C,C-trifluoro-methanesulfonamide → N-(3-((5-(4-cyanophenyl)oxazol-2-yl)amino)phenyl)-1,1,1-trifluoromethane sulfonamide
https://huagongshe.com/ja/reaction/537872
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | N-(3-Amino-phenyl)-C,C,C-trifluoro-methanesulfonamide | HCID 21757535 | — |
| 反応物 | 4-(2-Chlorooxazol-5-yl)benzonitrile | HCID 68443558 | — |
| 溶媒 | Isopropanol | HCID 3776 | — |
| 生成物 | N-(3-((5-(4-cyanophenyl)oxazol-2-yl)amino)phenyl)-1,1,1-trifluoromethane sulfonamide | HCID 71060232 | 76% |
反応手順
A mixture of 4-(2-chlorooxazol-5-yl)benzonitrile 2 (0.30 g, 1.47 mmol) and N-(3-aminophenyl)-1,1,1-trifluoromethanesulfonamide 43 (0.35 g, 1.45 mmol) in 2-propanol (25 mL) was heated to 80° C. for 14 h with stirring. Upon cooling, solvent was evaporated and silica column purified (Biotage) (Acetone/hexane as an eluent) to provide N-(3-((5-(4-cyanophenyl)oxazol-2-yl)amino)phenyl)-1,1,1-trifluoromethane sulfonamide 44 (0.45 g, 75% yield) as a solid. MS (ES) m/z 409 (M+H+).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US08865709B2 |
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| 出典データセット | uspto-grants-2014_10 |
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| ORD ID | ord-3626c877453a46bcbf016d2357f3a0ab |
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| 出典メモ | uspto-grants-2014_10 |
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