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1-Acetamido-2-nitro-3,5-bis(trifluoromethyl)benzene → 2-Nitro-3,5-bis(trifluoromethyl)aniline
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-Acetamido-2-nitro-3,5-bis(trifluoromethyl)benzene | HCID 19958574 | — |
| 溶媒 | Hydrochloric Acid | HCID 313 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 2-Nitro-3,5-bis(trifluoromethyl)aniline | HCID 19958571 | 71.2% |
反応手順
A mixture of 1-acetamido-2-nitro-3,5-bis(trifluoromethyl)benzene (200 mg, 0.63 mmol) in concentrated HCl (3 mL) and EtOH (3 mL) was refluxed overnight, then it was extracted by ethyl acetate (2×3 mL). The extract was dried over Mg2SO4 and evaporated to give 2-nitro-3,5-bis(trifluoromethyl)aniline 123 mg (71%). 1H NMR (DMSO-d6): δ 6.392 (s, 2H), 7.131 (s, 1H), 7.375 (s, 1H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05620979 |
| 出典データセット | uspto-grants-1997_04 |
| ORD ID | ord-9f6f7fdb7052411baadf954b48407654 |
| 出典メモ | uspto-grants-1997_04 |