Oxalic Acid → 6,7-Bis(trifluoromethyl)-1,4-dihydroquinoxaline-2,3-dione
反応式
[F:1][C:2]([F:16])([F:15])[C:3]1[C:8]([C:9]([F:12])([F:11])[F:10])=[CH:7][C:6]([NH2:13])=[C:5]([NH2:14])[CH:4]=1.[C:17](O)(=[O:21])[C:18](O)=[O:19]>Cl>[F:1][C:2]([F:15])([F:16])[C:3]1[CH:4]=[C:5]2[C:6](=[CH:7][C:8]=1[C:9]([F:12])([F:11])[F:10])[NH:13][C:18](=[O:19])[C:17](=[O:21])[NH:14]2参加物
4
実験手順
A mixture of 102 mg (0.418 mmol) of 4,5-bis(trifluoromethyl)-1,2-phenylenediamine and 37 mg (0.411 mmol) of oxalic acid in 2 mL of 2N HCl was refluxed for 6 h and cooled to room temperature. The mixture was filtered and washed by water, CHCl3 and dried to leave a colorless solid (43 mg, 35%), mp >250° C. 1H NMR (DMSO-d6), 7.629 (s, 2) 12.293 (s, 2). 19F NMR (DMSO-d6), 62.185 (s).
後処理
- temperaturewas refluxed for 6 h
- filtrationThe mixture was filtered
- washwashed by water, CHCl3
- customdried
出典と根拠
- ORDレコード
- ord-c443c11ddcb64bd0a6e62fcc14512a15
- 出典データセット
- uspto-grants-1997_04
- 特許番号
- US05620979
反応ノート
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