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Trimethyltin chloride → 5-Methyl-2-trimethylstannylbenzo[b]thiophene
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Trimethyltin chloride | HCID 14016 | — |
| 反応物 | Ammonium Chloride | HCID 25517 | — |
| 反応物 | 5-Methylbenzo(b)thiophene | HCID 84346 | — |
| 反応物 | Butyllithium | HCID 178418339 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 溶媒 | Hexane | HCID 8058 | — |
| 生成物 | 5-Methyl-2-trimethylstannylbenzo[b]thiophene | HCID 21848133 | — |
反応手順
A solution of 7.411 g of 5-methylbenzo[b]thiophene (Maybridge, Chemical Co. Ltd., 11-78) in 35 ml of ether is added dropwise at 0° to a mixture of 40 ml of 1.5N butyllithium in hexane and 40 ml of ether. After 30 minutes, a solution of 9.963 g of trimethyltin chloride in 50 ml of ether is also added dropwise at 0°. After stirring for 1 hour at 0°, 50 ml of 5% ammonium chloride solution are added. The product is obtained by extracting with 100 ml and 150 ml of ether. Distillation at 0.15 mbar and 100°-106° yields 5-methyl-2-trimethylstannylbenzo[b]thiophene.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05620998 |
| 出典データセット | uspto-grants-1997_04 |
| ORD ID | ord-aac6fa2d8f224448bf2aa8d745c21d9b |
| 出典メモ | uspto-grants-1997_04 |