関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Oxalyl chloride | HCID 65578 | — |
| 反応物 | 4-Fluorobenzamide | HCID 71572 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 4-Fluorobenzoyl isocyanate | HCID 2733375 | 100.9% |
反応手順
To a solution of 4-fluorobenzamide (1 g, 7.2 mmol) in DCM (25 mL) was added slowly oxalylchloride (0.76 mL, 8.62 mmol). The mixture was heated to 50° C. for ˜18 hr. The mixture was allowed to cool to room temperature and concentrated in vacuo to afford crude 4-fluorobenzoyl isocyanate (1.2 g). The crude material was used in the next step without further purification.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08865732B2 |
|---|
| 出典データセット | uspto-grants-2014_10 |
|---|
| ORD ID | ord-2036fb3f31d74ad28e98521a32791a68 |
|---|
| 出典メモ | uspto-grants-2014_10 |
|---|
