N-[2-(3,5-di-tert-butyl-4-hydroxyphenethyl)-4,6-difluorophenyl]-N'-(1-benzyl-4-piperidyl)urea → HCID 19960561、化合物
反応式
[C:1]([C:5]1[CH:6]=[C:7]([CH:35]=[C:36]([C:39]([CH3:42])([CH3:41])[CH3:40])[C:37]=1[OH:38])[CH2:8][CH2:9][C:10]1[CH:15]=[C:14]([F:16])[CH:13]=[C:12]([F:17])[C:11]=1[NH:18][C:19]([NH:21][CH:22]1[CH2:27][CH2:26][N:25]([CH2:28][C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)[CH2:24][CH2:23]1)=[O:20])([CH3:4])([CH3:3])[CH3:2].[ClH:43].C(OCC)(=O)C>C(O)C>[ClH:43].[C:39]([C:36]1[CH:35]=[C:7]([CH:6]=[C:5]([C:1]([CH3:4])([CH3:3])[CH3:2])[C:37]=1[OH:38])[CH2:8][CH2:9][C:10]1[CH:15]=[C:14]([F:16])[CH:13]=[C:12]([F:17])[C:11]=1[NH:18][C:19]([NH:21][CH:22]1[CH2:27][CH2:26][N:25]([CH2:28][C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)[CH2:24][CH2:23]1)=[O:20])([CH3:42])([CH3:41])[CH3:40]参加物
4
反応条件
- 温度
- 50 °C
実験手順
N-[2-(3,5-di-tert-butyl-4-hydroxyphenethyl)-4,6-difluorophenyl]-N'-(1-benzyl-4-piperidyl)urea (1.15 g) was suspended in ethanol (20 ml) and heated at 50° C. to dissolve it. To the solution was added 4N hydrochloric acid/ethyl acetate solution (anhydrous)(0.5 ml). This solution was concentrated to a volume of 5 ml, cooled to 0°-5° C. and allowed to stand for 4 hrs. The resultant crystals were filtered and dried to afford the title compound (1.00 g, 81%).