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Ethanol → Trifluoromethoxy phenyl-N-hydroxy-benzamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethanol | HCID 702 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | 4-(Trifluoromethoxy)benzonitrile | HCID 67621 | — |
| 反応物 | Hydroxyamine hydrochloride | HCID 443297 | — |
| 生成物 | Trifluoromethoxy phenyl-N-hydroxy-benzamide | HCID 86643274 | — |
反応手順
To a solution of 4-Trifluoromethoxybenzonitrile (1.0 g, 5.0 mmol) in EtOH (20 mL) was added hydroxylamine hydrochloride (0.365 g, 5.0 mmol) and NaOH (0.212 g, 5.0 mmol). The resulting reaction mixture was refluxed for 15 h. After the completion of the reaction (TLC monitoring), the mixture was concentrated, added EtOH and filtered. The filtrate was evaporated in vacuo and used as such for the next step (crude yield 12.0 g, 66%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08865736B2 |
| 出典データセット | uspto-grants-2014_10 |
| ORD ID | ord-07e7c7730ae3400bb48e061324818fb3 |
| 出典メモ | uspto-grants-2014_10 |