関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 1,3-Dichloroacetone | HCID 10793 | — |
| 反応物 | 4-Methoxybenzamide | HCID 76959 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | 4-(Chloromethyl)-2-(4-methoxyphenyl)-1,3-oxazole | HCID 19958794 | 87.1% |
反応手順
To a solution of 1,3 dichloroacetone (0.504 g, 3.90 mmol) in toluene (5 ml) was added 4-methoxy benzamide (0.30 g, 1.90 mmol). The reaction mixture was heated at 120° C. for 1 h. After the completion of the reaction mixture (TLC monitoring), the reaction mixture was evaporated to dryness under reduced pressure and the residue was purified over silica gel (230-400 M, 15% EtOAc-Hexane) to get the desired product (0.37 g, 83%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08865736B2 |
|---|
| 出典データセット | uspto-grants-2014_10 |
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| ORD ID | ord-251913861c1c40c8b1d5c54fd78d2d74 |
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| 出典メモ | uspto-grants-2014_10 |
|---|
