N-(4-Phenoxyphenyl)acetamide → N-(4-Phenoxy-phenyl)-thioacetamide

HRID 538617ノート

反応式

HRID 538617 の反応式
[O:1]([C:8]1[CH:13]=[CH:12][C:11]([NH:14][C:15](=O)[CH3:16])=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.COC1C=CC(P2(SP(C3C=CC(OC)=CC=3)(=S)S2)=[S:27])=CC=1>C1(C)C=CC=CC=1>[O:1]([C:8]1[CH:13]=[CH:12][C:11]([NH:14][C:15](=[S:27])[CH3:16])=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

4

反応物 2

HCID 80579N-(4-Phenoxyphenyl)acetamideHCID 87949Lawesson's reagent

生成物 1

HCID 59402779N-(4-Phenoxy-phenyl)-thioacetamide収率 86.6%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

反応条件

温度
120 °C

実験手順

To a solution of N-(4-phenoxy-phenyl)-acetamide (1.20 g, 5.28 mmol) in 10 ml of toluene was added Lawesson's reagent (1.50 g, 3.70 mmol). The reaction mixture was heated at 120° C. for 2 h. After the completion of the reaction (TLC monitoring), the reaction mixture was evaporated to dryness under reduced pressure. The residue was purified by column chromatography on silica (60-120 M) using ethyl acetate/hexane (5:95) as the eluent to provide the title compound (0.78 g, 60.7%).

後処理

  1. customAfter the completion of the reaction (TLC monitoring)
  2. customthe reaction mixture was evaporated to dryness under reduced pressure
  3. customThe residue was purified by column chromatography on silica (60-120 M)

出典と根拠

ORDレコード
ord-e571c8c8df594c3dbca6ee9ddc740d78
出典データセット
uspto-grants-2014_10
特許番号
US08865736B2

反応ノート

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