化工社化工社 化学情報印刷レポート · 研究参考用
Iodine → HCID 66851890、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Iodine | HCID 807 | — |
| 反応物 | 3,3-Dimethylbutanal | HCID 76335 | — |
| 反応物 | Potassium thiocyanate | HCID 516872 | — |
| 反応物 | 1-(Aminomethyl)cyclopentan-1-ol | HCID 13051202 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | HCID 66851890 | HCID 66851890 | 73.3% |
反応手順
A mixture of 1-(aminomethyl)cyclopentanol (prepared from cyclopentanone as described in WO 2006/100208) (3.5 g, 30 mmol), 3,3-dimethylbutanal (3.4 g, 33 mmol), 4 Å molecular sieves (4 g, 8-12 mesh beads), potassium thiocyanate (3.9 g, 40 mmol) and iodine (7.7 g, 30 mmol) in acetonitrile (50 mL) were processed as described in Example 18A to provide the title compound (5.6 g, 22 mmol, 72% yield). MS (DCI/NH3) m/z 255 (M+H)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08865753B2 |
| 出典データセット | uspto-grants-2014_10 |
| ORD ID | ord-a06a0d64612844a88d532f3050cdad5b |
| 出典メモ | uspto-grants-2014_10 |