Hydrochloric Acid → (R)-2-amino-2-(2,4-difluorophenyl)ethanol hydrochloride

HRID 539086ノート

反応式

HRID 539086 の反応式
[Si]([O:8][CH2:9][C@H:10]([NH:19][S@](C(C)(C)C)=O)[C:11]1[CH:16]=[CH:15][C:14]([F:17])=[CH:13][C:12]=1[F:18])(C(C)(C)C)(C)C.[ClH:26].O1CCOCC1>CO>[ClH:26].[NH2:19][C@H:10]([C:11]1[CH:16]=[CH:15][C:14]([F:17])=[CH:13][C:12]=1[F:18])[CH2:9][OH:8]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 67033078(S)-N-((R)-2-(tert-butyldimethylsilyloxy)-1-(2,4-difluorophenyl)ethyl)-2-methylpropane-2-sulfinamide

生成物 1

HCID 67034313(R)-2-amino-2-(2,4-difluorophenyl)ethanol hydrochloride収率 100%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

反応条件

温度
0 °C

実験手順

To a mixture of (S)—N—((R)-2-(tert-butyldimethylsilyloxy)-1-(2,4-difluorophenyl)ethyl)-2-methylpropane-2-sulfinamide (1.08 g, 2.76 mmol) in MeOH (8 mL) was added 4N HCl in dioxane (6.9 mL, 28 mmol) at 0° C. under N2. The reaction mixture was stirred at 0° C. for 4 hours. The solvents were evaporated in vacuo to give (R)-2-amino-2-(2,4-difluorophenyl)ethanol hydrochloride (0.58 g, 100%) as a white solid, which was used in the next step without further purification.

後処理

  1. customThe solvents were evaporated in vacuo

出典と根拠

ORDレコード
ord-dff5a1d4fce34cfa93aec2aff36da462
出典データセット
uspto-grants-2014_10
特許番号
US08865726B2

反応ノート

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