Benzylamine → N-benzylmethanesulfonamide

HRID 539600ノート

反応式

HRID 539600 の反応式
[CH2:1]([NH2:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:9][S:10](Cl)(=[O:12])=[O:11]>C(Cl)Cl.O>[CH2:1]([NH:8][S:10]([CH3:9])(=[O:12])=[O:11])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

5

反応物 2

HCID 7504BenzylamineHCID 31297Methanesulfonyl chloride2 回

生成物 1

HCID 235490N-benzylmethanesulfonamide

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 6344Dichloromethane溶媒

実験手順

18.27 g of benzylamine were dissolved in 100 ml of methylene chloride and, while cooling with ice, 6.00 ml of methanesulfonyl chloride were very slowly added dropwise. On completion of addition of the methanesulfonyl chloride, the reaction solution was diluted with 100 ml of water, and the aqueous phase was extracted again with 50 ml of methylene chloride. The combined organic phases were washed with 1 N aqueous hydrochloric acid, dried over MgSO4 and concentrated by rotary evaporation. This gave the product (14.40 g) with a molecular weight of 185.3 g/mol (C8H11NO2S).

後処理

  1. additionwere very slowly added dropwise
  2. extractionthe aqueous phase was extracted again with 50 ml of methylene chloride
  3. washThe combined organic phases were washed with 1 N aqueous hydrochloric acid
  4. dry with materialdried over MgSO4
  5. concentrationconcentrated by rotary evaporation

出典と根拠

ORDレコード
ord-54820aa9a05248b7923d1f9ef6cee000
出典データセット
uspto-grants-2014_10
特許番号
US08871758B2

反応ノート

読み込み中…