1,4-Dioxane hydrochloride → 4-(4-Cyanobenzyl)-4-hydroxypiperidine hydrochloride

HRID 539664ノート

反応式

HRID 539664 の反応式
[C:1]([C:3]1[CH:23]=[CH:22][C:6]([CH2:7][C:8]2([OH:21])[CH2:13][CH2:12][N:11](C(OC(C)(C)C)=O)[CH2:10][CH2:9]2)=[CH:5][CH:4]=1)#[N:2].[ClH:24].O1CCOCC1>O1CCOCC1>[ClH:24].[C:1]([C:3]1[CH:4]=[CH:5][C:6]([CH2:7][C:8]2([OH:21])[CH2:9][CH2:10][NH:11][CH2:12][CH2:13]2)=[CH:22][CH:23]=1)#[N:2]

参加物

4

反応物 2

HCID 204431481,4-Dioxane hydrochlorideHCID 70851493Tert-butyl 4-(4-cyanobenzyl)-4-hydroxypiperidine-1-carboxylate

生成物 1

HCID 866808464-(4-Cyanobenzyl)-4-hydroxypiperidine hydrochloride

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

To a solution of tert-butyl 4-(4-cyanobenzyl)-4-hydroxypiperidine-1-carboxylate (19 g) in 1,4-dioxane (50 mL) was added 4.0 M HCl/1,4-dioxane solution (76 mL) at 0° C., and the mixture was stirred at room temperature for 10 hr. The resulting solid was collected by filtration, washed with ethyl acetate (100 mL) and diethyl ether (200 mL), and dried under reduced pressure to give the title compound (9.3 g).

後処理

  1. filtrationThe resulting solid was collected by filtration
  2. washwashed with ethyl acetate (100 mL) and diethyl ether (200 mL)
  3. customdried under reduced pressure

出典と根拠

ORDレコード
ord-39bee5a4a4244673ab6ca7a39c8c9cb7
出典データセット
uspto-grants-2014_10
特許番号
US08871766B2

反応ノート

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