Hydrochloric Acid → 4-Fluoro-2-(pyridin-4-yl)benzoic acid hydrochloride
反応式
[F:1][C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8]C)=[O:7])=[C:4]([C:12]2[CH:17]=[CH:16][N:15]=[CH:14][CH:13]=2)[CH:3]=1.[ClH:18]>>[ClH:18].[F:1][C:2]1[CH:11]=[CH:10][C:5]([C:6]([OH:8])=[O:7])=[C:4]([C:12]2[CH:13]=[CH:14][N:15]=[CH:16][CH:17]=2)[CH:3]=1参加物
3
反応条件
- 温度
- 90 °C
実験手順
A mixture of methyl 4-fluoro-2-(pyridin-4-yl)benzoate (0.88 g) and 6 N hydrochloric acid (13 mL) was stirred at 90° C. for 18 hr. The solvent was evaporated under reduced pressure to give the title compound (0.96 g).
後処理
- customThe solvent was evaporated under reduced pressure
出典と根拠
- ORDレコード
- ord-ef5caa2c58c3419d9e4e2678d715daae
- 出典データセット
- uspto-grants-2014_10
- 特許番号
- US08871766B2
反応ノート
読み込み中…