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6-Amino-3-chloropyridazine → 6-Chloro-2-(4-methyl-3-nitro-phenyl)imidazo[2,1-f]pyridazine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 6-Amino-3-chloropyridazine | HCID 21643 | — |
| 反応物 | 2-Bromo-1-(4-methyl-3-nitrophenyl)ethan-1-one | HCID 3800422 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | 6-Chloro-2-(4-methyl-3-nitro-phenyl)imidazo[2,1-f]pyridazine | HCID 86667857 | 88.2% |
反応手順
A stirred solution of 6-chloropyridazin-3-amine (18.4 g, 0.14 mol) and 2-bromo-1-(4-methyl-3-nitro-phenyl)ethanone (36.13 g, 0.14 mol) in acetonitrile (219 mL) is heated at reflux for 18 hr. The mixture is diluted with water (500 mL), stirred at room temperature for 1 hour and solids are collected by filtration to give the title compound (35.65 g, 88% yield). LCMS m/z=289.4 [M+H]+, tR=2.65 min.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08871767B2 |
| 出典データセット | uspto-grants-2014_10 |
| ORD ID | ord-c6d8e6a97087478db212b0bdbb34b055 |
| 出典メモ | uspto-grants-2014_10 |