2,4-Dichloro-6-methylquinazoline → N-(3-Aminooxetan-3-ylmethyl)-2-chloro-6-methylquinazolin-4-amine
反応式
[Cl:1][C:2]1[N:11]=[C:10](Cl)[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([CH3:13])[CH:8]=2)[N:3]=1.[NH2:14][CH2:15][C:16]1([NH2:20])[CH2:19][O:18][CH2:17]1>CO>[NH2:20][C:16]1([CH2:15][NH:14][C:10]2[C:9]3[C:4](=[CH:5][CH:6]=[C:7]([CH3:13])[CH:8]=3)[N:3]=[C:2]([Cl:1])[N:11]=2)[CH2:19][O:18][CH2:17]1参加物
4
実験手順
A solution of 2,4-dichloro-6-methylquinazoline (645 mg, 3 mmol) and 3-(aminomethyl)oxetan-3-amine (340 mg, 3.3 mmol) in methanol (15 mL) was stirred at room temperature overnight. After the resulting mixture was concentrated in vacuo, the residue was purified by column chromatography (eluting with 10% methanol in dichloromethane) to afford the desired product.
後処理
- concentrationAfter the resulting mixture was concentrated in vacuo
- customthe residue was purified by column chromatography (eluting with 10% methanol in dichloromethane)
出典と根拠
- ORDレコード
- ord-463f9b1bff4f4f8cb51f8be1b520ec80
- 出典データセット
- uspto-grants-2014_10
- 特許番号
- US08871756B2
反応ノート
読み込み中…