Triethylamine → N-[(3-Aminooxetan-3-yl)methyl]-2-chloroquinazolin-4-amine

HRID 540202ノート

反応式

HRID 540202 の反応式
[Cl:1][C:2]1[N:11]=[C:10](Cl)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.[NH2:13][CH2:14][C:15]1([NH2:19])[CH2:18][O:17][CH2:16]1.C(N(CC)CC)C>CO>[NH2:19][C:15]1([CH2:14][NH:13][C:10]2[C:9]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[N:3]=[C:2]([Cl:1])[N:11]=2)[CH2:18][O:17][CH2:16]1

参加物

5

反応物 3

HCID 8471TriethylamineHCID 2528862,4-DichloroquinazolineHCID 217130163-(Aminomethyl)oxetan-3-amine

生成物 1

HCID 86691405N-[(3-Aminooxetan-3-yl)methyl]-2-chloroquinazolin-4-amine収率 92%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a solution of 2,4-dichloroquinazoline (1.0 g, 5.024 mmol) in methanol (15 mL) was added 3-(aminomethyl)oxetan-3-amine (855 mg, 60%, 5.024 mmol) and triethylamine (101 mg, 1.005 mmol). After being stirred at room temperature overnight, the mixture was concentrated in vacuo. The residue was purified by flash column chromatography to afford 1.2 g of the desired product as a white solid (yield was 92%).

後処理

  1. concentrationthe mixture was concentrated in vacuo
  2. customThe residue was purified by flash column chromatography

出典と根拠

ORDレコード
ord-ed5f1cc09e1e4dbab5a9729bda253ceb
出典データセット
uspto-grants-2014_10
特許番号
US08871756B2

反応ノート

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