2,3,4,5-Tetrahydrobenzo[f][1,4]thiazepine → HCID 71255080、化合物

HRID 540290ノート

反応式

HRID 540290 の反応式
[CH2:1]([O:8][C:9]1[C:18]2[C:13](=[CH:14][CH:15]=[C:16]([Br:19])[CH:17]=2)[N:12]=[C:11](Cl)[N:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[S:21]1[C:27]2[CH:28]=[CH:29][CH:30]=[CH:31][C:26]=2[CH2:25][NH:24][CH2:23][CH2:22]1>>[CH2:1]([O:8][C:9]1[C:18]2[C:13](=[CH:14][CH:15]=[C:16]([Br:19])[CH:17]=2)[N:12]=[C:11]([N:24]2[CH2:25][C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=3[S:21][CH2:22][CH2:23]2)[N:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

3

反応物 2

HCID 122691062,3,4,5-Tetrahydrobenzo[f][1,4]thiazepineHCID 86691432HCID 86691432、化合物

生成物 1

HCID 71255080HCID 71255080、化合物収率 62.7%

反応条件

温度
80 °C

実験手順

A mixture of 4-(benzyloxy)-6-bromo-2-chloroquinazoline (700 mg, 2.0 mmol) and 2,3,4,5-tetrahydro-1,4-benzothiazepine (990 mg, 6.0 mmol) was heated at 80° C. for 10 minutes. The resulting reaction mixture was cooled to room temperature and purified by silica gel column chromatography (eluting with dichloromethane) to afford 600 mg of the desired product as a white solid (yield was 62.7%).

後処理

  1. customThe resulting reaction mixture
  2. temperaturewas cooled to room temperature
  3. custompurified by silica gel column chromatography (eluting with dichloromethane)

出典と根拠

ORDレコード
ord-f6c540c3012b473aa009554a7e57de02
出典データセット
uspto-grants-2014_10
特許番号
US08871756B2

反応ノート

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