関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Ibuprofen, (+-)- | HCID 3672 | — |
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 1-Deoxy-1-(octylamino)-D-glucitol | HCID 90064 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | (S)-ibuprofen N-octyl-D-glucamine salt | HCID 131719976 | 83.3% |
反応手順
Racemic ibuprofen (18.03 g, 87.4 mmol), N-octyl-D-glucamine (12.12 g, 41.3 mmol), triethylamine (4.4 g, 43.5 mmol), water (0.5 mL), and toluene (150 mL) were heated to 80° C., forming a clear solution. The solution was cooled to 25° C. over 2 1/2 hours, then cooled in an ice bath to 15° C. The resulting crystalline precipitate was recovered by filtration, washed with toluene, and dried to give (S)-ibuprofen N-octyl-D-glucamine salt (17.2 g, 78.8% yield, 94.8% ee).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05621140 |
|---|
| 出典データセット | uspto-grants-1997_04 |
|---|
| ORD ID | ord-35ee6ae184d34e9e99eed5912c2385b9 |
|---|
| 出典メモ | uspto-grants-1997_04 |
|---|
