関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Ibuprofen, (+-)- | HCID 3672 | — |
| 反応物 | 1-Deoxy-1-(octylamino)-D-glucitol | HCID 90064 | — |
| 溶媒 | Isopropanol | HCID 3776 | — |
| 生成物 | (S)-ibuprofen N-octyl-D-glucamine salt | HCID 131719976 | 86% |
反応手順
Racemic ibuprofen (27.03, 131.03 mmol), N-octyl-D-glucamine (16.35 g, 55.73 mmol), and isopropanol (150 mL) were heated to 80° C., forming a clear solution, and the solution then cooled to 33° C. over 4 hours. The resulting precipitate was recovered by filtration, washed with isopropanol, and dried to give (S)-ibuprofen N-octyl-D-glucamine salt (23.95 g, 47.93 mmol, 73.2% yield, 99.0% ee).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05621140 |
|---|
| 出典データセット | uspto-grants-1997_04 |
|---|
| ORD ID | ord-64d11cbe56384d20a818716a090a8426 |
|---|
| 出典メモ | uspto-grants-1997_04 |
|---|
