化工社化工社 化学情報印刷レポート · 研究参考用
Hydrochloric Acid → Piperazine-1-carboxamide Hydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | 1-Piperazinecarboxamide | HCID 258192 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 生成物 | Piperazine-1-carboxamide Hydrochloride | HCID 2769700 | — |
反応手順
0.01 g of 1-[3(S)-[[N-(benzyloxycarbonyl)-L-asparaginyl]amino]-2(R)-hydroxy-4-phenylbutyl]-4-(tert.butoxycarbonyl)-N-tert.butyl-2(R or S)-piperazinecarboxamide (isomer B) was treated with hydrogen chloride in ethyl acetate as described in Example 97 to give 0.007 g of 1-[3(S)-[[N-(benzyloxycarbonyl)-L-asparaginyl]amino]-2(R)-hydroxy-4-phenylbutyl]-N-tert.butyl-2(R or S)-piperazinecarboxamide hydrochloride as a very hygroscopic solid; MS: m/e 597 [M+H]+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05620987 |
| 出典データセット | uspto-grants-1997_04 |
| ORD ID | ord-3ede6d1a165d4c67848822100762423c |
| 出典メモ | uspto-grants-1997_04 |