Methyl 3-(N'-hydroxycarbamimidoyl)-4-methylbenzoate → Methyl 3-carbamimidoyl-4-methylbenzoate

HRID 541185ノート

反応式

HRID 541185 の反応式
O[N:2]=[C:3]([C:5]1[CH:6]=[C:7]([CH:12]=[CH:13][C:14]=1[CH3:15])[C:8]([O:10][CH3:11])=[O:9])[NH2:4]>CO>[C:3]([C:5]1[CH:6]=[C:7]([CH:12]=[CH:13][C:14]=1[CH3:15])[C:8]([O:10][CH3:11])=[O:9])(=[NH:2])[NH2:4]

参加物

3

反応物 1

HCID 86672520Methyl 3-(N'-hydroxycarbamimidoyl)-4-methylbenzoate2 回

生成物 1

HCID 68288326Methyl 3-carbamimidoyl-4-methylbenzoate収率 57%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

反応条件

温度
25 °C

実験手順

A round-bottom flask, containing a solution of methyl 3-(N′-hydroxycarbamimidoyl)-4-methylbenzoate (compound 1.8, 8 g, 36.50 mmol, 1.00 equiv, 95%) in methanol (150 mL) was purged with nitrogen gas. To the solution was added palladium on carbon (9 g, 10%, 60% water) and the flask was then further purged with nitrogen gas. The atmosphere was then changed to hydrogen and the mixture was stirred overnight at 25° C. under a balloon. After purging the system with nitrogen, the solids were removed by filtration and the filtrate was concentrated under reduced pressure to yield 4 g (54%) of the title compound as a brown solid.

後処理

  1. customwas purged with nitrogen gas
  2. additionTo the solution was added palladium on carbon (9 g, 10%, 60% water)
  3. customthe flask was then further purged with nitrogen gas
  4. customAfter purging the system with nitrogen
  5. customthe solids were removed by filtration
  6. concentrationthe filtrate was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-ce747048371c4dd2a007705e0ff13e67
出典データセット
uspto-grants-2014_10
特許番号
US08871790B2

反応ノート

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