5-Nitro-2-(1-pyrrolidinyl)pyridine → 6-(Pyrrolidin-1-yl)pyridin-3-amine

HRID 541221

反応式

HRID 541221 の反応式
[N+:1]([C:4]1[CH:5]=[CH:6][C:7]([N:10]2[CH2:14][CH2:13][CH2:12][CH2:11]2)=[N:8][CH:9]=1)([O-])=O>C(O)C>[N:10]1([C:7]2[N:8]=[CH:9][C:4]([NH2:1])=[CH:5][CH:6]=2)[CH2:14][CH2:13][CH2:12][CH2:11]1

参加物

3

反応物 1

HCID 3168235-Nitro-2-(1-pyrrolidinyl)pyridine2 回

生成物 1

HCID 38991726-(Pyrrolidin-1-yl)pyridin-3-amine収率 98%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

Around-bottom flask, containing a solution of 5-nitro-2-(pyrrolidin-1-yl)pyridine (compound 40.1, 1.93 g, 10.00 mmol, 1.00 equiv) in ethanol (30 mL) was purged with nitrogen. Palladium on carbon (0.4 g, 10%, 60% water) was added. After further purging the system with nitrogen, the atmosphere was changed to hydrogen and the resulting mixture was stirred overnight at room temperature. After purging the system with nitrogen, the solids were filtered off and the filtrate was concentrated under reduced pressure and dried to yield 1.6 g (98%) of the title compound as a brown solid.

後処理

  1. customwas purged with nitrogen
  2. additionPalladium on carbon (0.4 g, 10%, 60% water) was added
  3. customAfter further purging the system with nitrogen
  4. customAfter purging the system with nitrogen
  5. filtrationthe solids were filtered off
  6. concentrationthe filtrate was concentrated under reduced pressure
  7. customdried

出典と根拠

ORDレコード
ord-08683304d07f4398a320d3dacf0cb6e4
出典データセット
uspto-grants-2014_10
特許番号
US08871790B2

関連ノート

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