Hydrochloric Acid → 6-(Piperidin-4-yl)nicotinonitrile hydrochloride
反応式
[C:1]([C:3]1[CH:4]=[CH:5][C:6]([CH:9]2[CH2:14][CH2:13][N:12](C(OC(C)(C)C)=O)[CH2:11][CH2:10]2)=[N:7][CH:8]=1)#[N:2].[ClH:22]>C(OCC)(=O)C>[ClH:22].[NH:12]1[CH2:11][CH2:10][CH:9]([C:6]2[CH:5]=[CH:4][C:3]([C:1]#[N:2])=[CH:8][N:7]=2)[CH2:14][CH2:13]1参加物
4
反応条件
- 温度
- 7.5 °C
実験手順
Through a solution of tert-butyl 4-(5-cyanopyridin-2-yl)piperidine-1-carboxylate (compound 50.2, 200 mg, 0.70 mmol, 1.00 equiv) in ethyl acetate (20 mL) was bubbled HCl gas. The resulting mixture was stirred for 40 min at 5-10° C. The resulting precipitate was collected by filtration and dried to yield 150 mg (97%) of the title compound as a white solid.
後処理
- filtrationThe resulting precipitate was collected by filtration
- customdried
出典と根拠
- ORDレコード
- ord-23be840a44d44791af03da026b9f4c04
- 出典データセット
- uspto-grants-2014_10
- 特許番号
- US08871790B2
反応ノート
読み込み中…