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HRID 541249作成日：2026年10月25日

2-Methoxyacetohydrazide → 4-(1-(5-(5-(Methoxymethyl)-4H-1,2,4-triazol-3-yl)-2,4-dimethylbenzoyl)piperidin-4-yl)benzonitrile

https://huagongshe.com/reaction/541249

反応式

関与物質

役割名称HCID仕込み量
反応物2-MethoxyacetohydrazideHCID 2759532—
反応物2-(Tetrahydrofuran-3-yl)acetohydrazideHCID 68288816—
反応物4-(1-(2,4-dimethyl-5-(5-((tetrahydrofuran-3-yl)methyl)-4H-1,2,4-triazol-3-yl)benzoyl)piperidin-4-yl)benzonitrileHCID 178424704—
生成物4-(1-(5-(5-(Methoxymethyl)-4H-1,2,4-triazol-3-yl)-2,4-dimethylbenzoyl)piperidin-4-yl)benzonitrileHCID 178494707—

反応手順

The title compound was prepared using standard chemical manipulations and procedures similar to those used for the preparation of 4-(1-(2,4-dimethyl-5-(5-((tetrahydrofuran-3-yl)methyl)-4H-1,2,4-triazol-3-yl)benzoyl)piperidin-4-yl)benzonitrile (compound 130), using 2-methoxyacetohydrazide (compound 190.6) instead of 2-(tetrahydrofuran-3-yl)acetohydrazide (compound 130.4). m/z (ES+) 430 (M+H)+.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US08871790B2
出典データセットuspto-grants-2014_10
ORD IDord-f458bbb2c4a242ddb42914512a877ec1
出典メモuspto-grants-2014_10