3-Amino-4-methylbenzohydrazide → HCID 68289152、化合物
反応式
CO[C:3]1[CH2:4][CH:5]([C:9]2[CH:16]=[CH:15][C:12]([C:13]#[N:14])=[CH:11][CH:10]=2)[CH2:6][CH2:7][N:8]=1.[NH2:17][C:18]1[CH:19]=[C:20]([CH:25]=[CH:26][C:27]=1[CH3:28])[C:21]([NH:23][NH2:24])=O>ClC1C=CC=CC=1Cl>[NH2:17][C:18]1[CH:19]=[C:20]([C:21]2[N:8]3[CH2:7][CH2:6][CH:5]([C:9]4[CH:16]=[CH:15][C:12]([C:13]#[N:14])=[CH:11][CH:10]=4)[CH2:4][C:3]3=[N:24][N:23]=2)[CH:25]=[CH:26][C:27]=1[CH3:28]参加物
4
反応条件
- 温度
- 150 °C
実験手順
To a solution of 4-(6-methoxy-2,3,4,5-tetrahydropyridin-4-yl)benzonitrile (compound 347.3, 5.00 g, 23.36 mmol, 1.00 equiv) in 1,2-dichlorobenzene (100 mL) was added 3-amino-4-methylbenzohydrazide (compound 347.4, 4.63 g, 28.0 mmol, 1.20 equiv). The resulting solution was stirred overnight at 150° C. in an oil bath. After cooling to ambient temperature, the resulting mixture was purified using silica gel column chromatography with dichloromethane/methanol (1:0˜100:1) as eluent to furnish 2.40 g (31%) of the title compound as a white solid.