Acetic Anhydride → HCID 19961181、化合物

HRID 54155ノート

反応式

HRID 54155 の反応式
[NH2:1][CH2:2][C:3]1[C:12]2[C:7](=[C:8]([OH:14])[C:9]([OH:13])=[CH:10][CH:11]=2)[CH2:6][CH:5]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[CH:4]=1.[C:21](OC(=O)C)(=[O:23])[CH3:22].C(N(CC)CC)C>C(Cl)Cl>[C:21]([NH:1][CH2:2][C:3]1[C:12]2[C:7](=[C:8]([OH:14])[C:9]([OH:13])=[CH:10][CH:11]=2)[CH2:6][CH:5]([C:15]2[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=2)[CH:4]=1)(=[O:23])[CH3:22]

参加物

5

反応物 3

HCID 7918Acetic AnhydrideHCID 8471TriethylamineHCID 199610761-Aminomethyl-3-phenyl-5,6-dihydroxy-3,4-dihydronaphthalene

生成物 1

HCID 19961181HCID 19961181、化合物

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

Approximately 1 mmol of 1-aminomethyl-3-phenyl-5,6-dihydroxy-3,4-dihydronaphthalene, from Example 2, was reacted with 1.2 mmol of acetic anhydride in the presence of 1.2 mmol of triethylamine in an excess of methylene chloride. The mixture was washed with 0.1N HCl, and dried. The product was precipitated by addition of ether, collected, and dried. mp 238° C. MS M/Z: 310. Anal. calc. for C19H19NO3.HBr C: 65.03; H, 5.72; N, 3.61; found: C, 73.46; H, 6.13; N, 4.49.

後処理

  1. washThe mixture was washed with 0.1N HCl
  2. customdried
  3. customThe product was precipitated by addition of ether
  4. customcollected
  5. customdried

出典と根拠

ORDレコード
ord-a2b8d786fd1e46ad9ded0093a3568413
出典データセット
uspto-grants-1997_04
特許番号
US05621133

反応ノート

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