3,5-Dimethylisoxazole-4-carbonyl Chloride → N-[6-Chloro-2,4,8,22-tetraazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20), 3(22),4,6,9(21),10,12,16,18-nonaen-12-yl]-1-[(3,5-dimethylisoxazol-4-yl)carbonyl]piperidine-4-carboxamide Trifluoroacetate

HRID 541588

反応式

HRID 541588 の反応式
[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].FC(F)(F)C(O)=O.[Cl:15][C:16]1[CH:17]=[N:18][C:19]2[NH:20][C:21]3[CH:22]=[CH:23][CH:24]=[C:25]([CH:46]=3)[CH2:26][CH2:27][C:28]3[CH:36]=[C:32]([NH:33][C:34]=1[N:35]=2)[CH:31]=[CH:30][C:29]=3[NH:37][C:38]([CH:40]1[CH2:45][CH2:44][NH:43][CH2:42][CH2:41]1)=[O:39].[CH3:47][C:48]1[C:52]([C:53](Cl)=[O:54])=[C:51]([CH3:56])[O:50][N:49]=1>>[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[Cl:15][C:16]1[CH:17]=[N:18][C:19]2[NH:20][C:21]3[CH:22]=[CH:23][CH:24]=[C:25]([CH:46]=3)[CH2:26][CH2:27][C:28]3[CH:36]=[C:32]([NH:33][C:34]=1[N:35]=2)[CH:31]=[CH:30][C:29]=3[NH:37][C:38]([CH:40]1[CH2:45][CH2:44][N:43]([C:53]([C:52]2[C:48]([CH3:47])=[N:49][O:50][C:51]=2[CH3:56])=[O:54])[CH2:42][CH2:41]1)=[O:39]

参加物

3

反応物 2

HCID 27362653,5-Dimethylisoxazole-4-carbonyl ChlorideHCID 86636132N-[6-Chloro-2,4,8,22-tetraazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20), 3(22),4,6,9(21),10,12,16,18-nonaen-12-yl]piperidine-4-carboxamide bis(trifluoroacetate)

生成物 1

HCID 86636135N-[6-Chloro-2,4,8,22-tetraazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20), 3(22),4,6,9(21),10,12,16,18-nonaen-12-yl]-1-[(3,5-dimethylisoxazol-4-yl)carbonyl]piperidine-4-carboxamide Trifluoroacetate収率 36%

実験手順

The desired compound was prepared according to the procedure of Example A20, using N-[6-chloro-2,4,8,22-tetraazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaen-12-yl]piperidine-4-carboxamide bis(trifluoroacetate) and 3,5-dimethylisoxazole-4-carbonyl chloride as starting materials in 36% yield. LCMS for C30H31ClN7O3 (M+H)+: m/z=572.2.

出典と根拠

ORDレコード
ord-e1836ed1be7b47febd7f95f5673a42fa
出典データセット
uspto-grants-2014_10
特許番号
US08871753B2

関連ノート

読み込み中…