戻る
化工社化工社 化学情報印刷レポート · 研究参考用
HRID 541691作成日：2026年10月26日

1-methyl-1H-imidazole-2-carboxylic acid → N-[6-Chloro-2,4,8,18,22-pentaazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaen-12-yl]-2-{1-[(1-methyl-1H-imidazol-2-yl)carbonyl]piperidin-4-yl}acetamide bis(trifluoroacetate)

https://huagongshe.com/reaction/541691

反応式

関与物質

役割名称HCID仕込み量
反応物1-methyl-1H-imidazole-2-carboxylic acidHCID 557678—
反応物N-[6-chloro-2,4,8,18,22-pentaazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaen-12-yl]-2-piperidin-4-ylacetamide bis(trifluoroacetate)HCID 86636208—
生成物N-[6-Chloro-2,4,8,18,22-pentaazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaen-12-yl]-2-{1-[(1-methyl-1H-imidazol-2-yl)carbonyl]piperidin-4-yl}acetamide bis(trifluoroacetate)HCID 8663621270%

反応手順

The desired compound was prepared according to the procedure of Example A27, using N-[6-chloro-2,4,8,18,22-pentaazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaen-12-yl]-2-piperidin-4-ylacetamide bis(trifluoroacetate) and 1-methyl-1H-imidazole-2-carboxylic acid as starting materials in 70% yield. LCMS for C29H31ClN9O2 (M+H)+: m/z=572.2.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US08871753B2
出典データセットuspto-grants-2014_10
ORD IDord-669e1b5bfb8d403581c42cb892006c5c
出典メモuspto-grants-2014_10