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HRID 541693作成日：2026年10月27日

4-Methyl-1,2,5-oxadiazole-3-carboxylic acid → N-[6-Chloro-2,4,8,18,22-pentaazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaen-12-yl]-2-{1-[(4-methyl-1,2,5-oxadiazol-3-yl)carbonyl]piperidin-4-yl}acetamide bis(trifluoroacetate)

https://huagongshe.com/reaction/541693

反応式

関与物質

役割名称HCID仕込み量
反応物4-Methyl-1,2,5-oxadiazole-3-carboxylic acidHCID 314768—
反応物N-[6-chloro-2,4,8,18,22-pentaazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaen-12-yl]-2-piperidin-4-ylacetamide bis(trifluoroacetate)HCID 86636208—
生成物N-[6-Chloro-2,4,8,18,22-pentaazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaen-12-yl]-2-{1-[(4-methyl-1,2,5-oxadiazol-3-yl)carbonyl]piperidin-4-yl}acetamide bis(trifluoroacetate)HCID 8663621444%

反応手順

The desired compound was prepared according to the procedure of Example A27, using N-[6-chloro-2,4,8,18,22-pentaazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaen-12-yl]-2-piperidin-4-ylacetamide bis(trifluoroacetate) and 4-methyl-1,2,5-oxadiazole-3-carboxylic acid as starting materials in 44% yield. LCMS for C28H29ClN9O3 (M+H)+: m/z=574.2.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US08871753B2
出典データセットuspto-grants-2014_10
ORD IDord-5dd37bc0b6d5402d91c1d59758403161
出典メモuspto-grants-2014_10