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HRID 541709作成日：2026年10月26日

5-Methyl-1,2-oxazole-4-sulfonyl chloride → N-[6-Chloro-2,4,8,18,22-pentaazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaen-12-yl]-2-{1-[(5-methylisoxazol-4-yl)sulfonyl]piperidin-4-yl}acetamide bis(trifluoroacetate)

https://huagongshe.com/reaction/541709

反応式

関与物質

役割名称HCID仕込み量
反応物5-Methyl-1,2-oxazole-4-sulfonyl chlorideHCID 2776141—
反応物N-[6-chloro-2,4,8,18,22-pentaazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaen-12-yl]-2-piperidin-4-ylacetamide tris(trifluoroacetate)HCID 86636131—
生成物N-[6-Chloro-2,4,8,18,22-pentaazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaen-12-yl]-2-{1-[(5-methylisoxazol-4-yl)sulfonyl]piperidin-4-yl}acetamide bis(trifluoroacetate)HCID 8663623012%

反応手順

The desired compound was prepared according to the procedure of Example A42 using N-[6-chloro-2,4,8,18,22-pentaazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaen-12-yl]-2-piperidin-4-ylacetamide tris(trifluoroacetate) and 5-methylisoxazole-4-sulfonyl chloride as starting materials in 12% yield. LCMS for C28H30ClN8O4S (M+H)+: m/z=609.2.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US08871753B2
出典データセットuspto-grants-2014_10
ORD IDord-0dd9baf7a6c444c088c3f158d2ca4dfc
出典メモuspto-grants-2014_10