Methanol → Methyl 3-bromo-5-nitrobenzoate

HRID 541736

反応式

HRID 541736 の反応式
[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([N+:11]([O-:13])=[O:12])[CH:10]=1)[C:5]([OH:7])=[O:6].S(=O)(=O)(O)O.[CH3:19]O>>[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([N+:11]([O-:13])=[O:12])[CH:10]=1)[C:5]([O:7][CH3:19])=[O:6]

参加物

4

反応物 3

HCID 887MethanolHCID 1118Sulfuric AcidHCID 2393363-Bromo-5-nitrobenzoic acid

生成物 1

HCID 239341Methyl 3-bromo-5-nitrobenzoate収率 95%

反応条件

温度
0 °C

実験手順

A solution of 3-bromo-5-nitrobenzoic acid (15.4 g, 62.6 mmol) in methanol (120 mL) and sulfuric acid (1.7 mL, 31 mmol) was heated to reflux overnight. After cooling to 0° C. for 0.5 h, the precipitated solid was filtered to give the desired product as a white solid (15.5 g, 95%). LCMS for C8H7BrNO4 (M+H)+: m/z=260.0, 262.0.

後処理

  1. temperatureto reflux overnight
  2. filtrationthe precipitated solid was filtered

出典と根拠

ORDレコード
ord-2847e7bb46cf4f01b532d26082e37923
出典データセット
uspto-grants-2014_10
特許番号
US08871753B2

関連ノート

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