Water → Methyl 3-aminopyrazinecarboxylate

HRID 54188

反応式

HRID 54188 の反応式
[NH2:1][C:2]1[C:3]([C:8]([OH:10])=[O:9])=[N:4][CH:5]=[CH:6][N:7]=1.S(=O)(=O)(O)O.O.[C:17](=O)(O)[O-].[Na+]>CO>[NH2:1][C:2]1[C:3]([C:8]([O:10][CH3:17])=[O:9])=[N:4][CH:5]=[CH:6][N:7]=1

参加物

6

反応物 4

HCID 962WaterHCID 1118Sulfuric AcidHCID 726563-Amino-2-pyrazinecarboxylic acidHCID 516892Sodium Bicarbonate

生成物 1

HCID 72669Methyl 3-aminopyrazinecarboxylate収率 63%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

3-Aminopyrazine-2-carboxylic acid (55.5 g, 0.4 mol) is suspended in 400 mL of methanol, cooled in an ice bath and concentrated sulfuric acid (80 mL) is gradually added with stirring and stirring then continued for 48 hours at room temperature. The resulting dark brown solution is poured into 700 mL of water containing sodium bicarbonate (160 g). The brown crystalline solid which precipitates is collected and dried. The crude product is purified by recrystallization from water to yield the product as yellow needles in 63% yield, melting point 169°-170° C.

後処理

  1. temperaturecooled in an ice bath
  2. stirringstirring
  3. customThe brown crystalline solid which precipitates
  4. customis collected
  5. customdried
  6. customThe crude product is purified by recrystallization from water

出典と根拠

ORDレコード
ord-68e3a5907b6a46749902e095f4074eb3
出典データセット
uspto-grants-1997_04
特許番号
US05622913

関連ノート

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