化工社化工社 化学情報印刷レポート · 研究参考用
Diazomethane diethylether → methyl 1-(4-(N-methylaminosulfonyl)phenyl)methylene-5-methoxy-2-methyl-1H-3-indenylacetate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Diazomethane diethylether | HCID 21186548 | — |
| 反応物 | methyl 1-(4-aminosulfonylphenyl)methylene-5-methoxy-2-methyl-1H-3-indenylacetate | HCID 70401818 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | methyl 1-(4-(N-methylaminosulfonyl)phenyl)methylene-5-methoxy-2-methyl-1H-3-indenylacetate | HCID 67583673 | 29% |
反応手順
A solution of 4a (100 mg) in methanol (20 ml) was treated with excess diazomethane ether solution to give two products. They are separated via preparative tlc using 1500 μm silica gel plates developed 3 times with 5% ethyl acetate in chloroform to give Z methyl 1-(4-(N-methylaminosulfonyl)phenyl)methylene-5-methoxy-2-methyl-1H-3-indenylacetate (6a) (30 mg, 29% yield): m.p. 167°-169° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04656190 |
| 出典データセット | uspto-grants-1987_04 |
| ORD ID | ord-444feaece30a4ad5bb8930ec7d2f63d3 |
| 出典メモ | uspto-grants-1987_04 |