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HRID 542231作成日：2026年10月27日
Ethanol → 2-(4-Acetylaminophenoxy)ethyl 2,6-dimethyl-5-(2-methylthioethoxycarbonyl)-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylate
https://huagongshe.com/reaction/542231
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Ethanol | HCID 702 | — |
| 反応物 | 2-Methylthioethyl 3-aminocrotonate | HCID 19803016 | — |
| 反応物 | 2-(4-Acetylaminophenoxy)ethyl 2-(3-nitrobenzylidene)acetylacetate | HCID 57315737 | — |
| 生成物 | 2-(4-Acetylaminophenoxy)ethyl 2,6-dimethyl-5-(2-methylthioethoxycarbonyl)-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylate | HCID 20151274 | 80% |
反応手順
15 g (0.04 moles) of 2-(4-acetylaminophenoxy)ethyl 2-(3-nitrobenzylidene)acetylacetate and 6.37 g (0.04 moles) of 2-methylthioethyl 3-aminocrotonate are heated under reflux in 30 ml of ethanol during 8 hours. The solution is then cooled to -5° C. to obtain 2-(4-acetylaminophenoxy)ethyl 2,6-dimethyl-5-(2-methylthioethoxycarbonyl)-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylate as yellow crystals melting--after recrystallisation in ethanol--at 76° C.-80° C. The yield is 80% of the theoretical yield.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US04656181 |
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| 出典データセット | uspto-grants-1987_04 |
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| ORD ID | ord-8aee582f035746cf9380b565fe717282 |
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| 出典メモ | uspto-grants-1987_04 |
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