関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Sulfuric Acid | HCID 1118 | — |
| 反応物 | Propylurea | HCID 12303 | — |
| 反応物 | N-Nitroaniline | HCID 61191 | — |
| 反応物 | (2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanal | HCID 107526 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | N-propyl-N'(beta-D-glucosyl)-N-nitrosourea | HCID 13345998 | — |
反応手順
A mixture of 3.6 g of D-glucose, 2.3 g of propylurea, 0.2 g of nitroaniline and 0.1 ml of a concentrated sulphuric acid is heated at reflux for 10 minutes in 15 ml of methanol. The residue in the amount of 2.6 g is separated, added with 15 ml of glacial acetic acid, 8 ml of distilled water, 1.8 g of sodium nitrite and stirred at the temperature of -1° C. for 2 hours. The solution is evaporated, the residue is recrystallized from methanol to give 2.32 g (80% of the theoretical) of the product. M.p. 110° C. (decomposition), [α]D -5° (CH3OH), Rf =0.81. Found, %: N 14.12. Calculated, %: N 14.33.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US04656259 |
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| 出典データセット | uspto-grants-1987_04 |
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| ORD ID | ord-9c9cb849a7f24119a47989326318d543 |
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| 出典メモ | uspto-grants-1987_04 |
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