関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Butylurea | HCID 11595 | — |
| 反応物 | N-Nitroaniline | HCID 61191 | — |
| 反応物 | (2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanal | HCID 107526 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | N-butyl-N'-(beta-D-glucosyl)-N-nitrosourea | HCID 13346001 | 669.7% |
反応手順
A mixture of 3.6 g of D-glucose, 2.8 g of butylurea, 0.2 g of nitroaniline and 0.15 ml of a concentrated hydrochloric acid in 10 ml of methanol is heated at reflux for 20 minutes. The resulting precipitate in the amount of 3 g is separated and added with 15 ml of glacial acetic acid, 10 ml of distilled water, 1.8 g of sodium nitrite and stirred at the temperature of -1° C. for 2 hours to give 2.98 g of the product (90% of the thoretical), hydroscopic, [α]D -1° (CH3OH), Rf =0.85. Found, %: N 13.47. Calculated, % N 13.68.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US04656259 |
|---|
| 出典データセット | uspto-grants-1987_04 |
|---|
| ORD ID | ord-7d9ad15dac5d4f31933a8a05d57d8313 |
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| 出典メモ | uspto-grants-1987_04 |
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