N-[(6-Methoxypyridin-2-yl)methyl]acetamide → (6-Methoxypyridin-2-yl)methanamine

HRID 542262ノート

反応式

HRID 542262 の反応式
C([NH:4][CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([O:12][CH3:13])[N:7]=1)(=O)C.Cl.NCC1C=CC=C(OC)N=1.Cl.NCC1NC(=O)C=CC=1>Cl>[NH2:4][CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([O:12][CH3:13])[N:7]=1

参加物

5

反応物 3

HCID 13882972N-[(6-Methoxypyridin-2-yl)methyl]acetamideHCID 13882974(6-Methoxypyridin-2-yl)methanamine hydrochlorideHCID 212435226-(Aminomethyl)pyridin-2(1H)-one hydrochloride

生成物 1

HCID 13882973(6-Methoxypyridin-2-yl)methanamine

試薬・触媒・溶媒 1

HCID 313Hydrochloric Acid溶媒

実験手順

The crude product, 2-acetamidomethyl-6-methoxypyridine from Example 1, was combined with 10 ml of 6N hydrochloric acid, and the resulting mixture was heated at its reflux temperature for about 16 hours. The mixture was evaporated to provide a tan solid residue. The product was determined by infrared and nuclear magnetic resonance spectral analyses to be a mixture of 2-aminomethyl-6-methoxypyridine hydrochloride and 6-aminomethyl-2(1H)-pyridone hydrochloride.

後処理

  1. temperaturethe resulting mixture was heated at its
  2. temperaturereflux temperature for about 16 hours
  3. customThe mixture was evaporated
  4. customto provide a tan solid residue

出典と根拠

ORDレコード
ord-662e8a4a14424aeb82e9c2522529e6aa
出典データセット
uspto-grants-1987_04
特許番号
US04656285

反応ノート

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