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Methyl propiolate → 1,2,3,5-Tetrahydro-1-(2-chloro-5-pyridylmethyl)-8-nitroimidazo[1,2-a]pyridin-5-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methyl propiolate | HCID 13536 | — |
| 反応物 | 2-Chloro-5-{[2-(nitromethylidene)imidazolidin-1-yl]methyl}pyridine | HCID 180957 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | 1,2,3,5-Tetrahydro-1-(2-chloro-5-pyridylmethyl)-8-nitroimidazo[1,2-a]pyridin-5-one | HCID 14675671 | 52.3% |
反応手順
A mixed solution of 2-nitromethylene-3-(2-chloro-5-pyridylmethyl) imidazolidine (12.7 g), propiolic acid methyl ester (4.2 g) and methanol (100 ml) was refluxed under heating for about 20 hours. Subsequently methanol was distilled off under reduced pressure, and the residue was refined by a silica-gel column chromatography to give the desired 1,2,3,5-tetrahydro-1-(2-chloro-5-pyridylmethyl)-8-nitroimidazo[1,2-a]pyridin-5-one (8 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05622956 |
| 出典データセット | uspto-grants-1997_04 |
| ORD ID | ord-d891a446f4b24759aefd04538f82426b |
| 出典メモ | uspto-grants-1997_04 |