2-Bromo-2-phenylacetaldehyde → p-Nitroacetophenone

HRID 542278ノート

反応式

HRID 542278 の反応式
BrC[C:3]1[CH:8]=[C:7]([N+:9]([O-:11])=[O:10])[CH:6]=[CH:5][C:4]=1[C:12]([C:14]1C=CC([N+]([O-])=O)=CC=1CBr)=[O:13].BrC(C1C=CC=CC=1)C=O>>[N+:9]([C:7]1[CH:6]=[CH:5][C:4]([C:12](=[O:13])[CH3:14])=[CH:3][CH:8]=1)([O-:11])=[O:10]

参加物

3

反応物 2

HCID 108889012-Bromo-2-phenylacetaldehydeHCID 86741403Bromomethyl-p-nitro-phenyl-ketone

生成物 1

HCID 7487p-Nitroacetophenone収率 98%

実験手順

One proceeds according to Example 14 but bromomethyl-p-nitro-phenyl-ketone is used as starting material in the place of α-bromo-α-phenyl-acetaldehyde. The reaction mixture is not worked up by the extraction method according to Example 14 but by precipitating the product with 50 ml of water, filtering off the same and washing it three times with 20 ml of water each. Thus 16.1 g of the desired compound are obtained, yield 98%.

後処理

  1. extractionThe reaction mixture is not worked up by the extraction method
  2. customby precipitating the product with 50 ml of water
  3. filtrationfiltering off the same and
  4. washwashing it three times with 20 ml of water each

出典と根拠

ORDレコード
ord-da7cefb13510455987f10dbb2632f5d7
出典データセット
uspto-grants-1987_04
特許番号
US04656290

反応ノート

読み込み中…