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Ammonia → Ethyl 3-amino-2-phenylpropyl(diethoxymethyl)phosphinate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ammonia | HCID 222 | — |
| 反応物 | Ethyl 3-nitro-2-phenylpropyl(diethoxymethyl)phosphinate | HCID 14362826 | — |
| 反応物 | HCID 178418361 | HCID 178418361 | — |
| 触媒 | Nickel | HCID 935 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | Ethyl 3-amino-2-phenylpropyl(diethoxymethyl)phosphinate | HCID 14362832 | — |
反応手順
A solution of 5.7 g of ethyl 3-nitro-2-phenylpropyl(diethoxymethyl)phosphinate in 60 ml of ethanol is added to 50 g of an 8% solution of ammonia in ethanol. To this are added 9 ml of Raney Nickel and the resulting mixture is hydrogenated at 1 bar until the theoretical amount of hydrogen has been taken up. The mixture is then filtered and the filtrate is concentrated under reduced pressure to give ethyl 3-amino-2-phenylpropyl(diethoxymethyl)phosphinate as a viscous oil, 31P=+44.4 ppm (CDCl3).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04656298 |
| 出典データセット | uspto-grants-1987_04 |
| ORD ID | ord-2fd2ce54650b4344b9506549685b0c86 |
| 出典メモ | uspto-grants-1987_04 |