Potassium cyanate → N-[4-(5-Oxo-4,5-dihydropyrazin-2-yl)phenyl]urea

HRID 542463

反応式

HRID 542463 の反応式
Cl.[NH2:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[N:10]=[CH:11][C:12](=[O:15])[NH:13][CH:14]=2)=[CH:5][CH:4]=1.[O-:16][C:17]#[N:18].[K+]>O.CN(C)C1C=CN=CC=1>[NH:2]([C:3]1[CH:4]=[CH:5][C:6]([C:9]2[N:10]=[CH:11][C:12](=[O:15])[NH:13][CH:14]=2)=[CH:7][CH:8]=1)[C:17]([NH2:18])=[O:16]

参加物

5

反応物 2

HCID 11378442Potassium cyanateHCID 197942325-(4-Aminophenyl)-2(1H)-pyrazinone hydrochloride

生成物 1

HCID 13853577N-[4-(5-Oxo-4,5-dihydropyrazin-2-yl)phenyl]urea

試薬・触媒・溶媒 2

HCID 142844-(Dimethylamino)pyridine触媒HCID 962Water溶媒

実験手順

5-(4-Aminophenyl)-2(1H)-pyrazinone hydrochloride (1.0 g) was dissolved in water (25 ml), to which solution potassium cyanate (0.4 g) and 4-dimethylaminopyridine (about 0.005 g) were added. The mixture was stirred at room temperature for 18 hours and the resulting suspended material collected by filtration. This was washed in hot dimethylformamide (30 ml), the insoluble material being collected and washed with water to afford the title compound, m.p. >300° C.; n.m.r. δ (DMSO-d6) 5.90 (s, 2H, --CONH2), 7.98, 8.10 (2d, 2H, pyridine H's); ν (liquid paraffin) 1710, 1665 cm-1.

後処理

  1. additionwere added
  2. filtrationcollected by filtration
  3. washThis was washed in hot dimethylformamide (30 ml)
  4. customthe insoluble material being collected
  5. washwashed with water

出典と根拠

ORDレコード
ord-d5b7d78fdc07470980cafc7d40871642
出典データセット
uspto-grants-1987_04
特許番号
US04657906

関連ノート

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