Potassium Carbonate → 2-isopropylamino-5-methyl-4H-3,1-benzoxazin-4-one
反応式
Cl.[CH:2]([NH:5][C:6]1[O:11][C:10](=[O:12])[C:9]2[C:13]([CH3:17])=[CH:14][CH:15]=[CH:16][C:8]=2[N:7]=1)([CH3:4])[CH3:3].C(=O)([O-])[O-].[K+].[K+]>CCOCC>[CH:2]([NH:5][C:6]1[O:11][C:10](=[O:12])[C:9]2[C:13]([CH3:17])=[CH:14][CH:15]=[CH:16][C:8]=2[N:7]=1)([CH3:4])[CH3:3]参加物
4
実験手順
1.0 g of 2-isopropylamino-5-methyl-4H-3,1-benzoxazin-4-one HCl suspended in 50 ml of ether is stirred with a twofold stoichiometric excess of dilute aqueous potassium carbonate solution until the salt is completely dissolved. The organic layer is then separated, washed twice with water, dried over magnesium sulfate and evaporated to yield 2-isopropylamino-5-methyl-4H-3,1-benzoxazin-4-one as the free base.
後処理
- dissolutionis completely dissolved
- customThe organic layer is then separated
- washwashed twice with water
- dry with materialdried over magnesium sulfate
- customevaporated
出典と根拠
- ORDレコード
- ord-c2c5a0de98144dba954e5555c74c2695
- 出典データセット
- uspto-grants-1987_04
- 特許番号
- US04657893
反応ノート
読み込み中…