Piperidine → HCID 21814160、化合物

反応式

Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[N:9][CH:10]=2)[N:5]=[CH:4][CH:3]=1.[NH:12]1[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]1.[NH2:18][NH2:19]>>[N:12]1([C:2]2[C:11]3[C:6](=[CH:7][CH:8]=[N:9][CH:10]=3)[N:5]=[CH:4][CH:3]=2)[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]1.[NH:18]([C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[N:9][CH:10]=2)[N:5]=[CH:4][CH:3]=1)[NH2:19]

参加物

反応物 3

HCID 8082Piperidine

HCID 9321Hydrazine

HCID 217666944-Chloro-1,6-naphthyridine

生成物 2

HCID 21814160HCID 21814160、化合物

HCID 23270930HCID 23270930、化合物

実験手順

Paudler et al., J. Heterocyclic Chem. 2 (4), 393-8 (1965), show the synthesis and NMR spectra of various 4-substituted-1,6-naphthyridines, for example, the reaction of 4-hydroxy-1,6-naphthyridine with POBr3 or POCl3 to obtain 4-bromo-1,6-naphthyridine or 4-chloro-1,6-naphthyridine, respectively. Also shown is the reaction of 4-bromo-1,6-naphthyridine with dimethylamine to produce 4-dimethylamino-1,6-naphthyridine and the reaction 4-chloro-1,6-naphthyridine with piperidine or hydrazine to produce 4-(1-piperidinyl)-1,6-naphthyridine or 4-hydrazino-1,6-naphthyridine, respectively.

出典と根拠

ORDレコード: ord-813bd2637e224677b9d60feff40d8fde
出典データセット: uspto-grants-1987_04
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US04657915

反応ノート

読み込み中…