化工社化工社 化学情報印刷レポート · 研究参考用
Tris(furan-2-yl)phosphane → 2,4-Diamino-6-methyl-5-[3-(4-chlorophenyl)-3-oxo-1-propenyl]pyrimidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Tris(furan-2-yl)phosphane | HCID 521585 | — |
| 反応物 | 5-Iodo-6-methylpyrimidine-2,4-diamine | HCID 15855792 | — |
| 反応物 | 1-Oxo-1-(4-chlorophenyl)-3-tributylstannyl-2-propene | HCID 67632895 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 2,4-Diamino-6-methyl-5-[3-(4-chlorophenyl)-3-oxo-1-propenyl]pyrimidine | HCID 53794185 | — |
反応手順
This compound is prepared in a manner analogous to that of Step E of Example 4, using 2.9 grams of (0.0064 mole) of 1-oxo-1-(4-chlorophenyl)-3-tributylstannyl-2-propene, 1.2 grams (0.0048 mole) of 2,4-diamino-5-iodo-6-methylpyrimidine (prepared in Step B of Example 3), 0.04 gram of tri-2-furylphosphine and 0.04 gram (catalyst) of tris(dibenzylidineacetone)dipalladium(0) in 30 mL of N,N-dimethylformamide, yielding 2,4-diamino-6-methyl-5-[3-(4-chlorophenyl)-3-oxo-1-propenyl]pyrimidine.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05622954 |
| 出典データセット | uspto-grants-1997_04 |
| ORD ID | ord-971f2e7a68da453ba8b23abb58bd156e |
| 出典メモ | uspto-grants-1997_04 |