Hydroxylamine → 5,6-difluoro-2,3-dihydro-1H-indole-2,3-dione
反応式
[F:1][C:2]1[CH:3]=[C:4]([CH:6]=[CH:7][C:8]=1[F:9])[NH2:5].Cl[C:11](Cl)(Cl)[CH:12]([OH:14])O.NO.S(=O)(=O)(O)[OH:20]>>[F:9][C:8]1[CH:7]=[C:6]2[C:4](=[CH:3][C:2]=1[F:1])[NH:5][C:11](=[O:20])[C:12]2=[O:14]参加物
5
実験手順
Reaction of 3,4-difluoroaniline with chloral hydrate and hydroxylamine followed cyclization with sulfuric acid, in a manner analogous to Parts A and B of Preparation 3, gave 5,6-difluoroisatin, which was reacted with hydrazine hydrate followed by sodium methoxide in ethanol, in a manner analogous to Preparation 1, to give the title compound, m.p. 187°-90° C.
後処理
- customin a manner analogous to Parts A and B of Preparation 3
出典と根拠
- ORDレコード
- ord-32452db7293742f48acc1800f278366a
- 出典データセット
- uspto-grants-1987_04
- 特許番号
- US04658037
反応ノート
読み込み中…