Hydrogen iodide → 4-Iodo-6-methoxypyrimidin-2-amine

HRID 542656ノート

反応式

HRID 542656 の反応式
[NH2:1][C:2]1[N:7]=[C:6](Cl)[CH:5]=[C:4]([O:9][CH3:10])[N:3]=1.[IH:11]>O.C(=O)([O-])[O-].[K+].[K+]>[NH2:1][C:2]1[N:7]=[C:6]([I:11])[CH:5]=[C:4]([O:9][CH3:10])[N:3]=1

参加物

5

反応物 2

HCID 24841Hydrogen iodideHCID 798112-Pyrimidinamine, 4-chloro-6-methoxy-

生成物 1

HCID 138244654-Iodo-6-methoxypyrimidin-2-amine

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 11430Potassium Carbonate溶媒

実験手順

18.0 g of 2-amino-4-chloro-6-methoxypyrimidine was added to 65 mL of 57% aqueous hydroiodic acid with ice bath cooling. The resulting thick mixture was kept at ambient temperature for 65 hours, diluted with water and neutralized with potassium carbonate. The solid was collected and recrystallized from aqueous ethanol to give 5.0 g of white crystals, m.p. 141.5°-144° C.

後処理

  1. temperaturecooling
  2. customThe solid was collected
  3. customrecrystallized from aqueous ethanol

出典と根拠

ORDレコード
ord-a3ee4e4c332e4672a411cc41f630d79b
出典データセット
uspto-grants-1987_04
特許番号
US04659361

反応ノート

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