Benzoic acid, 2-(isocyanatosulfonyl)-, methyl ester → HCID 13824466、化合物

HRID 542657ノート

反応式

HRID 542657 の反応式
[NH2:1][C:2]1[N:7]=[C:6]([I:8])[CH:5]=[C:4]([O:9][CH3:10])[N:3]=1.[C:11]([C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=1[S:21]([N:24]=[C:25]=[O:26])(=[O:23])=[O:22])([O:13][CH3:14])=[O:12]>C(Cl)Cl>[I:8][C:6]1[CH:5]=[C:4]([O:9][CH3:10])[N:3]=[C:2]([NH:1][C:25]([NH:24][S:21]([C:16]2[CH:17]=[CH:18][CH:19]=[CH:20][C:15]=2[C:11]([O:13][CH3:14])=[O:12])(=[O:23])=[O:22])=[O:26])[N:7]=1

参加物

4

反応物 2

HCID 156281Benzoic acid, 2-(isocyanatosulfonyl)-, methyl esterHCID 138244654-Iodo-6-methoxypyrimidin-2-amine

生成物 1

HCID 13824466HCID 13824466、化合物収率 20.4%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a solution of 0.25 g of 2-amino-4-iodo-6-methoxypyrimidine in 5 mL of dry methylene chloride was added 0.30 g 2-carbomethoxybenzenesulfonyl isocyanate. The resulting solution was allowed to stand for 20 hours at ambient temperature. The solution was cooled in an ice bath and crystallization induced with scratching. The crystals were collected, washed with n-butylchloride and dried to afford 0.10 g of the title compound, m.p. b 194°-196° C. (dec).

後処理

  1. temperatureThe solution was cooled in an ice bath
  2. customcrystallization
  3. customThe crystals were collected
  4. washwashed with n-butylchloride
  5. customdried

出典と根拠

ORDレコード
ord-1cb89b47bfd947bcb3453fe73b8772ec
出典データセット
uspto-grants-1987_04
特許番号
US04659361

反応ノート

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