Hydrochloric Acid → (4,6-Dimethylpyrimidin-2-yl)cyanamide

HRID 542678

反応式

HRID 542678 の反応式
[C:1]([NH:3][C:4]([NH2:6])=[NH:5])#[N:2].[CH3:7][C:8](=O)[CH2:9][C:10](=O)[CH3:11].Cl>O>[C:1]([NH:3][C:4]1[N:6]=[C:10]([CH3:11])[CH:9]=[C:8]([CH3:7])[N:5]=1)#[N:2]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 31261AcetylacetoneHCID 178418324HCID 178418324、化合物

生成物 1

HCID 521618(4,6-Dimethylpyrimidin-2-yl)cyanamide収率 70%

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
120 °C

実験手順

A mixture of 42 g (0.5 mol) of cyanoguanidine ("dicyanodiamide") and 50 g (0.5 mol) of pentane-2,4-dione ("acetylacetone") is heated to 120° C. for 15 hours. Thereafter, after the reaction mixture has been cooled, 500 ml of water are added and the solution is acidified with hydrochloric acid at 0° C. to 10° C. The product obtained in crystalline form in this procedure is isolated by being filtered off under suction. 51.8 g (70% of theory) of 2-cyanoamino-4,6-dimethyl-pyrimidine of melting point 205° C. are obtained.

後処理

  1. temperatureThereafter, after the reaction mixture has been cooled
  2. customThe product obtained in crystalline form in this procedure
  3. customis isolated
  4. filtrationby being filtered off under suction

出典と根拠

ORDレコード
ord-f14adb14524b4b93912b188aaac680b6
出典データセット
uspto-grants-1987_04
特許番号
US04659364

関連ノート

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